- Where to for precision treatment of HNF1A-MODY?
Maturity-onset diabetes of the young (MODY) represents an autosomal dominant genetic form of diabetes, coined by Tattersall and Fajans in 1974 as having one or more variations in a single gene . MODY is initially characterised by fasting hyperglycaemia, often diagnosed in children or young adults. Currently, MODY accounts for 1–5% of all individuals with …Continue reading “Where to for precision treatment of HNF1A-MODY?”
- Probing the interactions between air bubbles and (bio)interfaces at the nanoscale using FluidFM technology
Understanding the molecular mechanisms underlying bubble-(bio)surfaces interactions is currently achallenge that if overcame, would allow to understand and control the various processes in which theyare involved. Atomic force microscopy is a useful technique to measure such interactions, but it is limitedby the large size and instability of the bubbles that it can use, attached either … - Radionuclides from the Fukushima Daiichi Nuclear Power Plant in terrestrial systems
Abstract The 2011 Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, Japan, released the largest quantity of radionuclides into the terrestrial environment since the 1986 accident at Chernobyl. This accident resulted in 2.7 PBq of radiocaesium (137Cs) contaminated forests, agricultural lands, grasslands and urban areas, which subsequently migrated through soil and waterways in the Fukushima Prefecture. In … - Australasian Diabetes Congress 2020 – SGLT2 and Glucagon secretion by Caroline Bonner (Pasteur Lille)
According to the International Diabetes Federation, 463 million people are living with diabetes. Obesitycontributes to 65-80% of new cases of type 2 diabetes (T2D). T2D is a complex metabolic disorder, the pathogenesis of which is not understood. Impaired insulin sensitivity, hyperglucagonemia, endogenous glucose production (EGP), and islet cell dysfunction are major traits of the disease, … - A luminal unfolding microneedle injector for oral delivery of macromolecules – Nature Medicine
“A luminal unfolding microneedle injector for oral delivery of macromolecules” Abstract Insulin and other injectable biologic drugs have transformed the treatment of patients suffering from diabetes1,2, yet patients and healthcare providers often prefer to use and prescribe less effective orally dosed medications3,4,5. Compared with subcutaneously administered drugs, oral formulations create less patient discomfort4, show greater … - Graphical abstract “The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release”
Bonner et al JCI insight 2018 Graphical Abstract https://www.cell.com/cell-reports/fulltext/S2211-1247(19)30899-X - Transplantation of Human IPSC-RPE
Institut de la Vision – Olivier Goureau
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